Effects of calcium antagonists on high-energy phosphates in ischemic rat brain measured by 31P NMR spectroscopy.

Abstract

The effects of various calcium antagonists on the ATP, PCr, and Pi levels as well as intracellular pH in normal and ischemic rat brain were examined by 31P NMR spectroscopy using a surface coil. None of the calcium antagonists tested showed any effect in the nonischemic rat brain. However, when global ischemia was induced by cardiac arrest, the ensuring… (More)

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