Effects of calcium antagonists on serotonin-dependent aggregation and serotonin transport in platelets of patients with migraine

@article{Pukhalskaya2007EffectsOC,
  title={Effects of calcium antagonists on serotonin-dependent aggregation and serotonin transport in platelets of patients with migraine},
  author={T. G. Pukhal'skaya and Olga A. Kolosova and M. Yu. Men’shikov and A. M. Vein},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2007},
  volume={130},
  pages={633-635}
}
Flunarizine and cinnarizine (IC50 6.8×10−6 and 2.8×10−5 M, respectively) inhibited3H-serotonin uptake by platelets. In higher doses, they blocked serotonin-induced platelet aggregation and stimulated3H-serotonin release from these cells. Imipramine did not affect serotonin-releasing effects of preparations. In all patients cinnarizine was more potent in inhibiting serotonin uptake, and in half of the patients cinnarizine displayed higher activity as an inductor of serotonin release. 
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6 Citations
Background Citations
2
Results Citations
1

6 Citations

Flunarizine is a Highly Potent Inhibitor of Cardiac hERG Potassium Current
TLDR
The effects of flunarizine on potassium currents through cardiac channels encoded by the human ether-a-go-go related gene (hERG) stably expressed in CHO cells are examined with standard whole-cell voltage-clamp techniques.
Episodic Spontaneous Hypothermia Potentially Triggered by Hyperinsulinemia
TLDR
Treatment with flunarizine, a drug considered the first line in the treatment of migraine-related disorders, was started with a resulting reduction in the episodes and hyperinsulinemia is suggested as a potential mechanism for episodic spontaneous hypothermia.
Cinnarizine- and flunarizine-associated movement disorder: a literature review
  • J. Rissardo, A. Caprara
  • Medicine, Psychology
    The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
  • 2020
TLDR
Parkinsonism was the most well described MD and myoclonus was the poorest described MD with missing data about the neurological examination and electrodiagnostic studies.
Flunarizine for the prevention of migraine
TLDR
The evidence from randomized controlled trials on the effectiveness and tolerability of flunarizine for preventing migraine attacks in adults is described and assessed.
Recent Advances in Delivery Systems and Therapeutics of Cinnarizine: A Poorly Water Soluble Drug with Absorption Window in Stomach
TLDR
The paper provides insight to the approaches to overcome low and erratic bioavailability of cinnarizine by cyclodextrin complexes and novel dosage forms: self-nanoemulsifying systems and buoyant microparticulates.
Flunarizine for the prevention of migraine

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