Effects of calcium and of the Vitamin D system on skeletal and calcium homeostasis: lessons from genetic models

@article{Goltzman2004EffectsOC,
  title={Effects of calcium and of the Vitamin D system on skeletal and calcium homeostasis: lessons from genetic models},
  author={David Goltzman and Dengshun Miao and D. K. Panda and Geoffrey N Hendy},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2004},
  volume={89–90},
  pages={485-489}
}
Targeted deletion of genes encoding the 1,25-dihydroxyVitamin D [1,25(OH)(2)D]-synthesizing enzyme, 25 hydroxyVitamin D-1alpha-hydroxylase [1alpha(OH)ase or CYP27B1], and of the nuclear receptor for 1,25(OH)(2)D, the Vitamin D receptor (VDR), have provided useful mouse models of the inherited human diseases, Vitamin D-dependent rickets types I and II. We employed these models and double null mutants to examine the effects of calcium and of the 1,25(OH)(2)D/VDR system on skeletal and calcium… CONTINUE READING
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