Effects of calcitonin gene-related peptide (CGRP) and isoproterenol on the contractility and adenylate cyclase activity in the rat heart.

@article{Ishikawa1987EffectsOC,
  title={Effects of calcitonin gene-related peptide (CGRP) and isoproterenol on the contractility and adenylate cyclase activity in the rat heart.},
  author={Tomoyoshi Ishikawa and Naomichi Okamura and Akira Saito and Kazuhiro Goto},
  journal={Journal of molecular and cellular cardiology},
  year={1987},
  volume={19 8},
  pages={723-7}
}
The occurrence of calcitonin gene-related peptide (CGRP) has been predicted by the study of the calcitonin gene of rats [1]. Recently CGRP was isolated from porcine spinal cord [3], and thus, CGRP is assumed to be a neuropeptide. It has been shown that CGRP exhibits potent positive chronotropic and inotropic effects on the atrial muscles of rats and guinea-pigs [5, 9, 11] . We have previously demonstrated the presence of nonadrenergic noncholinergic (NANC) nerves in the atria of rats and guinea… CONTINUE READING
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