Effects of caffeine on Ca-activated force production in skinned cardiac and skeletal muscle fibres of the rat

@article{Wendt1983EffectsOC,
  title={Effects of caffeine on Ca-activated force production in skinned cardiac and skeletal muscle fibres of the rat},
  author={Igor Wendt and D George Stephenson},
  journal={Pfl{\"u}gers Archiv},
  year={1983},
  volume={398},
  pages={210-216}
}
Skinned fibres prepared by mechanical and/or chemical means from cardiac and skeletal muscles of the rat were activated in solution strongly buffered for Ca2+ (with 50 mM EGTA) in the absence or presence of caffeine 5–40 mM. In all preparations caffeine was found to reversibly shift the relation between steady-state force and free [Ca2+] toward lower free [Ca2+] in a dose dependent manner. This increase in apparent Ca2+ sensitivity was not antagonized by procaine and was the same, within each… CONTINUE READING

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