Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity.

@article{Haertter2003EffectsOC,
  title={Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity.},
  author={Sebastian Haertter and Anna Nordmark and D Rose and Leif Bertilsson and Gunnel Tybring and Kari Laine},
  journal={British journal of clinical pharmacology},
  year={2003},
  volume={56 6},
  pages={679-82}
}
AIMS The aim of this study was to assess the influence of concomitant caffeine intake on the pharmacokinetics of oral melatonin, a probe drug for CYP1A2 activity. METHODS Twelve healthy subjects, six smokers and six nonsmokers, were given melatonin (6 mg) either alone or in combination with caffeine (3 x 200 mg). Blood samples for the analysis of melatonin or caffeine and paraxanthine were taken from 1 h before until 6 h after intake of melatonin. Subjects were genotyped with respect to the… CONTINUE READING

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