Effects of caffeine and 3-isobutyl-1-methylxanthine on voltage-activated potassium currents in vertebrate neurones and secretory cells.

@article{Reiser1996EffectsOC,
  title={Effects of caffeine and 3-isobutyl-1-methylxanthine on voltage-activated potassium currents in vertebrate neurones and secretory cells.},
  author={M A Reiser and Theresa D'Souza and Stuart E Dryer},
  journal={British journal of pharmacology},
  year={1996},
  volume={118 8},
  pages={
          2145-51
        }
}
1. The effects of caffeine and 3-isobutyl-l-methylxanthine (IBMX) on voltage-activated K+ currents were examined by use of patch clamp recording techniques in dissociated chick autonomic ganglion neurones, chick pineal cells and rat anterior pituitary cells. 2. In chick ciliary ganglion neurones, caffeine (0.1-10 mM) produced a robust blockade of delayed rectifier K+ currents (IDR). Blockade was rapid in onset and concentration- and voltage-dependent. Caffeine produced greater inhibition with… CONTINUE READING

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