Effects of cGMP-dependent phosphorylation on rat and human connexin43 gap junction channels

  title={Effects of cGMP-dependent phosphorylation on rat and human connexin43 gap junction channels},
  author={Brenda R Kwak and Juan C S{\'a}ez and Ronald Wilders and Marc Chanson and Glenn I. Fishman and Elliot L. Hertzberg and David Conover Spray and Habo J. Jongsma},
  journal={Pfl{\"u}gers Archiv},
The effects of 8-bromoguanosine 3′:5′-cyclic monophosphate (8Br-cGMP), a membrane-permeant activator of protein kinase G (PKG), were studied on rat and human connexin43 (Cx43), the most abundant gap junction protein in mammalian heart, which were exogenously expressed in SKHep1 cells. Under dual whole-cell voltage-clamp conditions, 8Br-cGMP decreased gap junctional conductance (gj) in rat Cx43-transfected cells by 24.0±3.7% (mean±SEM, n=5), whereas gj was not affected in human Cx43-transfected… CONTINUE READING


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