Effects of cAMP-phosphodiesterase isozyme inhibitor on cytokine production by lipopolysaccharide-stimulated human peripheral blood mononuclear cells.

@article{Yoshimura1997EffectsOC,
  title={Effects of cAMP-phosphodiesterase isozyme inhibitor on cytokine production by lipopolysaccharide-stimulated human peripheral blood mononuclear cells.},
  author={Tomoaki Yoshimura and Chikako Kurita and Takuya Nagao and Eiseki Usami and Toshiya Nakao and S. Watanabe and Joji Kobayashi and Futoshi Yamazaki and H. Tanaka and Hiroichi Nagai},
  journal={General pharmacology},
  year={1997},
  volume={29 4},
  pages={
          633-8
        }
}
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses
  • S. JinM. Conti
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
TLDR
It is demonstrated that PDE4B gene activation by LPS constitutes a feedback regulation essential for an efficient immune response and was associated with a more than 90% decrease in tumor necrosis factor-α mRNA accumulation.
Regulation of leukocyte cytokine production by inhibitors of intracellular signalling pathways.
TLDR
The observation that PDE4 inhibitors can regulate monocyte cytokine generation further supports the view that these agents could have therapeutic benefit in a number of inflammatory diseases such as asthma, arthritis and inflammatory bowel disease.
Vasoactive intestinal peptide inhibits IL-8 production in human monocytes.
The role of phosphodiesterase 4B in IL-8/LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor
TLDR
The results suggest that PDE4B does not play an important role during the chemotactic response of human neutrophils.
Human lung and monocyte-derived macrophages differ with regard to the effects of β2-adrenoceptor agonists on cytokine release
TLDR
Concentrations of β2-adrenoceptor agonists that cause relaxation of the human bronchus can inhibit cytokine production by LPS-stimulated MDMs but not by LMs.
Dialyzable Leukocyte Extract differentially regulates the production of TNFα, IL-6, and IL-8 in bacterial component-activated leukocytes and endothelial cells
TLDR
The present data indicate the differential regulation by DLE of the production of TNFα, IL-6, and IL-8 cytokines, associated with effects on TLR2 and TLR4 expression and NF-κB and cAMP activities.
Roflumilast Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α and Chemokine Production by Human Lung Parenchyma
TLDR
Addition of formoterol to roflumilast provided superior in vitro anti-inflammatory activity, which may translate into greater efficacy in COPD.
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Theophylline, pentoxifylline and 3-isobutyl-1-methylxanthine markedly suppress the lipopolysaccharide (LPS)-induced synthesis of TNF-alpha in human mononuclear cells, which may contribute to their beneficial effects in animal models of septic shock or lung injury and may have clinical implications.
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TLDR
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