Effects of butylated hydroxyanisole on acetaminophen hepatotoxicity and glucuronidation in vivo.

@article{Hazelton1986EffectsOB,
  title={Effects of butylated hydroxyanisole on acetaminophen hepatotoxicity and glucuronidation in vivo.},
  author={G A Hazelton and J J Hjelle and Curtis D. Klaassen},
  journal={Toxicology and applied pharmacology},
  year={1986},
  volume={83 3},
  pages={474-85}
}
The present study examined the effects of butylated hydroxyanisole (BHA) on acetaminophen-induced hepatotoxicity and metabolism in vivo with emphasis on possible changes in the glucuronidation pathway. Female Swiss-Webster mice received BHA in the diet (1% w/w) for 12 days (600 to 800 mg/kg/day). BHA prevented acetaminophen hepatotoxicity (600 mg/kg, ip), based on serum alanine and aspartate aminotransferase activities and histopathological examination. The rate of elimination of acetaminophen… CONTINUE READING

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