Effects of buspirone on plasma neurotransmitters in healthy subjects

  title={Effects of buspirone on plasma neurotransmitters in healthy subjects},
  author={F. Lechin and B. van der Dijs and H. Jara and B. Orozco and S. Baez and M. Benaim and M. Lechin and A. Lech{\'i}n},
  journal={Journal of Neural Transmission},
  • F. Lechin, B. van der Dijs, +5 authors A. Lechín
  • Published 1998
  • Medicine, Psychology
  • Journal of Neural Transmission
  • Summary. Buspirone is an anxiolytic drug which exerts several central effects. It antagonizes presynaptic inhibitory DA2 autoreceptors at dopaminergic neurons and acts as an agonist for 5-HT1A inhibitor autoreceptors at serotonergic cells. Thus, buspirone respectively enhances and depresses the firing rates of both type of neurons. At doses which correlate with dopaminergic stimulation, but not 5-HT inhibition, buspirone also increases the firing rates of the central noradrenergic cells. We… CONTINUE READING
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