Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats

@article{Kitamura2010EffectsOB,
  title={Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats},
  author={Yoshihisa Kitamura and Takahiko Yagi and Kouhei Kitagawa and K A - NEDO Shinomiya and Hiromu Kawasaki and Masato Asanuma and Yutaka Gomita},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2010},
  volume={382},
  pages={151-158}
}
The dopamine reuptake inhibitor bupropion has clinically been proven to improve depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and further analyzed the possible role of dopamine receptors in this effect. Additionally, the mechanism by which bupropion acts in this model was explored specifically in relation to the site of action through the use of microinjections… CONTINUE READING
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