Effects of bupropion on body weight.


Patients' weights were assessed during placebo-controlled, amitriptyline-controlled, and uncontrolled bupropion trials. Low-moderate (50-450 mg/day) to moderate-high (300-750 mg/day) doses of bupropion were consistently associated with a lack of weight gain (average weight loss of 1-2 pounds); placebo was associated with an average weight gain of 1 lb and 75-225 mg/day of amitriptyline was associated with an increase of 3-9 lb. Bupropion treatment was rarely accompanied by reports of appetite change and had no statistically significant effect on caloric intake when compared to placebo.


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@article{HartoTruax1983EffectsOB, title={Effects of bupropion on body weight.}, author={Nancy E. Harto-Truax and Warren C. Stern and Lene Lindberg Miller and Takao L. Sato and Allen Cato}, journal={The Journal of clinical psychiatry}, year={1983}, volume={44 5 Pt 2}, pages={183-6} }