Effects of buprenorphine versus buprenorphine/naloxone tablets in non-dependent opioid abusers

@article{Strain2000EffectsOB,
  title={Effects of buprenorphine versus buprenorphine/naloxone tablets in non-dependent opioid abusers},
  author={Eric C. Strain and Kenneth B Stoller and Sharon L. Walsh and George E. Bigelow},
  journal={Psychopharmacology},
  year={2000},
  volume={148},
  pages={374-383}
}
Abstract Rationale: Buprenorphine is an opioid agonist-antagonist under development in the United States as a sublingual medication for treatment of opioid dependence. Buprenorphine may be abused; therefore, tablets combining buprenorphine with naloxone have been developed with the intent of reducing the abuse risk in people physically dependent upon opioids. The characteristics and abuse potential of buprenorphine and buprenorphine/naloxone tablets in non-dependent opioid abusers have not been… 
Acute effects of intramuscular and sublingual buprenorphine and buprenorphine/naloxone in non-dependent opioid abusers
TLDR
It is suggested that buprenorphine and bup Renorphine/naloxone have similar abuse potential in non-dependent opioid abusers, and that the addition of nalox one at these doses and in this dose ratio confers no evident advantage for decreasing the abuse potential of intramuscular or sublingual bupenorphine in this population.
Effects of buprenorphine/naloxone in opioid-dependent humans
TLDR
Intramuscular injection of buprenorphine/naloxone precipitates withdrawal in opioid dependent persons; therefore, the combination has a low abuse potential by the injection route in this population.
Blockade of hydromorphone effects by buprenorphine/naloxone and buprenorphine
TLDR
The addition of naloxone to buprenorphine may deter the parenteral abuse of bupRenorphine/nalox one, but it does not enhance the therapeutic efficacy of bu prenorphines.
Self-Administration of Intravenous Buprenorphine and the Buprenorphine/Naloxone Combination by Recently Detoxified Heroin Abusers
  • S. Comer, E. Collins
  • Biology, Medicine
    Journal of Pharmacology and Experimental Therapeutics
  • 2002
TLDR
Results demonstrate that both BUP and BUP/NX served as reinforcers under these conditions and that they may have similar abuse liability in recently detoxified individuals who abuse heroin.
Buprenorphine: how to use it right.
Pharmacokinetics and Subjective Effects of Sublingual Buprenorphine, Alone or in Combination with Naloxone
TLDR
Less than dose-proportional increases in plasma buprenorphine concentrations may contribute to the observed plateau for most pharmacodynamic effects as the dose is increased, according to the evaluated pharmacokinetics and pharmacodynamics of expected therapeutic doses.
Buprenorphine and Naloxone for Heroin Dependence
TLDR
The buprenorphine/naloxone combination product should be considered for use in primary care office-based settings as a safe and effective treatment that is likely to increase the availability of agonist treatment for opioid dependence.
Foreseeable Advantages and Limits of Buprenorphine-Naloxone Association
TLDR
The BupNx combination product may be interesting for use in primary care office-based settings as a safe and an effective treatment that is likely to increase the availability of agonist treatment for opioid dependence.
Re v iew Buprenorphine : how to use it right
TLDR
The buprenorphine plus naloxone combination product should provide additional safeguards for use in office-based practice by decreasing risk of diversion, and office- based treatment should expand the availability of services to opioid dependent patients.
The clinical efficacy and abuse potential of combination buprenorphine–naloxone in the treatment of opioid dependence
TLDR
The addition of naloxone does not appear to affect the efficacy of buprenorphine as a maintenance drug and the combination will reduce, but not eliminate, intravenous misuse; clinicians need to monitor patients in OST, and be selective in providing patients with medication to be taken without observation.
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