Effects of buprenorphine versus buprenorphine/naloxone tablets in non-dependent opioid abusers

  title={Effects of buprenorphine versus buprenorphine/naloxone tablets in non-dependent opioid abusers},
  author={Eric C. Strain and Kenneth B Stoller and Sharon L. Walsh and George E. Bigelow},
Abstract Rationale: Buprenorphine is an opioid agonist-antagonist under development in the United States as a sublingual medication for treatment of opioid dependence. Buprenorphine may be abused; therefore, tablets combining buprenorphine with naloxone have been developed with the intent of reducing the abuse risk in people physically dependent upon opioids. The characteristics and abuse potential of buprenorphine and buprenorphine/naloxone tablets in non-dependent opioid abusers have not been… 
Acute effects of intramuscular and sublingual buprenorphine and buprenorphine/naloxone in non-dependent opioid abusers
It is suggested that buprenorphine and bup Renorphine/naloxone have similar abuse potential in non-dependent opioid abusers, and that the addition of nalox one at these doses and in this dose ratio confers no evident advantage for decreasing the abuse potential of intramuscular or sublingual bupenorphine in this population.
Effects of buprenorphine/naloxone in opioid-dependent humans
Intramuscular injection of buprenorphine/naloxone precipitates withdrawal in opioid dependent persons; therefore, the combination has a low abuse potential by the injection route in this population.
Blockade of hydromorphone effects by buprenorphine/naloxone and buprenorphine
The addition of naloxone to buprenorphine may deter the parenteral abuse of bupRenorphine/nalox one, but it does not enhance the therapeutic efficacy of bu prenorphines.
Self-Administration of Intravenous Buprenorphine and the Buprenorphine/Naloxone Combination by Recently Detoxified Heroin Abusers
  • S. Comer, E. Collins
  • Biology, Medicine
    Journal of Pharmacology and Experimental Therapeutics
  • 2002
Results demonstrate that both BUP and BUP/NX served as reinforcers under these conditions and that they may have similar abuse liability in recently detoxified individuals who abuse heroin.
Buprenorphine: how to use it right.
Pharmacokinetics and Subjective Effects of Sublingual Buprenorphine, Alone or in Combination with Naloxone
Less than dose-proportional increases in plasma buprenorphine concentrations may contribute to the observed plateau for most pharmacodynamic effects as the dose is increased, according to the evaluated pharmacokinetics and pharmacodynamics of expected therapeutic doses.
Buprenorphine and Naloxone for Heroin Dependence
The buprenorphine/naloxone combination product should be considered for use in primary care office-based settings as a safe and effective treatment that is likely to increase the availability of agonist treatment for opioid dependence.
Foreseeable Advantages and Limits of Buprenorphine-Naloxone Association
The BupNx combination product may be interesting for use in primary care office-based settings as a safe and an effective treatment that is likely to increase the availability of agonist treatment for opioid dependence.
Re v iew Buprenorphine : how to use it right
The buprenorphine plus naloxone combination product should provide additional safeguards for use in office-based practice by decreasing risk of diversion, and office- based treatment should expand the availability of services to opioid dependent patients.
The clinical efficacy and abuse potential of combination buprenorphine–naloxone in the treatment of opioid dependence
The addition of naloxone does not appear to affect the efficacy of buprenorphine as a maintenance drug and the combination will reduce, but not eliminate, intravenous misuse; clinicians need to monitor patients in OST, and be selective in providing patients with medication to be taken without observation.


Buprenorphine and naloxone combinations: the effects of three dose ratios in morphine-stabilized, opiate-dependent volunteers
Buprenorphine with naloxone in ratios of 2:1 and 4:1 produced moderate to high increases in global opiate withdrawal, bad drug effect, and sickness, and these dose ratios also decreased the pleasurable effects and estimated street value of buprenorphines, thereby suggesting a low abuse liability.
Buprenorphine: dose-related blockade of opioid challenge effects in opioid dependent humans.
The results of this study confirm previous reports of buprenorphine blockade of opioid agonist effects in humans and extent those findings by demonstrating both a bup Renorphine dose-effect function and a dissociation between the potency of bu prenorphin's opioid blockade for self-report vs. physiological measures.
Buprenorphine vs methadone maintenance treatment for concurrent opioid dependence and cocaine abuse.
The results support the superiority of higher daily buprenorphine and methadone maintenance doses vs lower doses for reducing illicit opioid use, but the results do not support the superior of bupenorphine compared with methamphetamineadone for reducing cocaine use.
A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts
The results of this clinical trial indicated that buprenorphine was acceptable to patients and as effective as methadone in the detoxification treatment of heroin addicts.
Use of buprenorphine in the treatment of opiate addiction. I. Physiologic and behavioral effects during a rapid dose induction
It is indicated that a rapid dose induction with buprenorphine is acceptable to heroin‐dependent persons and that it causes minimal withdrawal symptoms.
Sublingual versus subcutaneous buprenorphine in opiate abusers
Both sublingual and subcutaneous buprenorphine have a similar profile of effects in opiate abusers, and both have a significant degree of miosis.
Subjective and physiologie effects of intravenous buprenorphine in humans
It is indicated that buprenorphine has substantial potential for abuse when administered intravenously and illicit intravenous self‐administration suggests that it may have a greater abuse potential by this route of administration.