Effects of bronchodilator particle size in asthmatic patients using monodisperse aerosols.

  title={Effects of bronchodilator particle size in asthmatic patients using monodisperse aerosols.},
  author={Omar Sharif Usmani and Martyn Francis Biddiscombe and Julia Anne Nightingale and S. R. Underwood and Peter J Barnes},
  journal={Journal of applied physiology},
  volume={95 5},
Aerosol particle size influences airway drug deposition. Current inhaler devices are inefficient, delivering a heterodisperse distribution of drug particle sizes where, at best, 20% reaches the lungs. Monodisperse aerosols are the appropriate research tools to investigate basic aerosol science concepts within the human airways. We hypothesized that engineering such aerosols of albuterol would identify the ideal bronchodilator particle size, thereby optimizing inhaled therapeutic drug delivery… CONTINUE READING
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