Effects of bromohomoibotenate on metabotropic glutamate receptors.

@article{Thomsen1994EffectsOB,
  title={Effects of bromohomoibotenate on metabotropic glutamate receptors.},
  author={Christian Fr\okjaer Thomsen and A. Bau and Poul Faarup and Christian Foged and Anders B Kanstrup and Peter D. Suzdak},
  journal={Neuroreport},
  year={1994},
  volume={5 18},
  pages={2417-20}
}
(S)-Bromohomoibotenic acid [(S)-BrHIbo] stereoselectively antagonized glutamate-stimulated phosphoinositide (PI) hydrolysis in baby hamster kidney (BHK) cells expressing mGluR1a in a competitive manner with an IC50 of 250 microM. However, (S)-BrHIbo did not inhibit (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD]-induced PI hydrolysis in rat… CONTINUE READING