Effects of bright light on responsiveness to a muscarinic agonist in rats selectively bred for endogenously increased cholinergic function

@article{Overstreet1990EffectsOB,
  title={Effects of bright light on responsiveness to a muscarinic agonist in rats selectively bred for endogenously increased cholinergic function},
  author={David H. Overstreet and Steven C. Dilsaver and David S. Janowsky and Amir Hosein Rezvani},
  journal={Psychiatry Research},
  year={1990},
  volume={33},
  pages={139-150}
}
The Flinders Sensitive Line (FSL) was derived from the Sprague-Dawley rat by selectively breeding those animals exhibiting a high level of sensitivity to an anticholinesterase. The Flinders Resistant Line (FRL) was simultaneously developed as a control line. These lines exhibit nonoverlapping distributions of their thermic responsiveness to oxotremorine. Bright light prevents the development of supersensitivity to oxotremorine occurring as a result of forced stress or treatment with a… CONTINUE READING
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