Effects of bone morphogenetic protein-2 on human neonatal calvaria cell differentiation.

@article{Hay1999EffectsOB,
  title={Effects of bone morphogenetic protein-2 on human neonatal calvaria cell differentiation.},
  author={Elizabeth Hay and Monique Hott and A. M. Graulet and Abderrahim Lomri and Pierre Jacques Marie},
  journal={Journal of cellular biochemistry},
  year={1999},
  volume={72 1},
  pages={81-93}
}
Bone morphogenetic proteins (BMPs) are factors that promote osteoblastic cell differentiation and osteogenesis. It is unknown whether BMPs may act on human osteoblastic cells by increasing immature cell growth and/or differentiation. We investigated the short- and long-term effects of recombinant human (rh)BMP-2 on cell growth and osteoblast phenotype in a new model of human neonatal pre-osteoblastic calvaria cells (HNC). In short-term culture, rhBMP-2 (20-100 ng/ml) inhibited DNA synthesis and… CONTINUE READING

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