Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice

@article{Raoul2007EffectsOB,
  title={Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice},
  author={William Raoul and Orianne Wagner-Ballon and Guitanouch Saber and Anne Hulin and Elisabeth Marcos and St{\'e}phane Giraudier and William Vainchenker and Serge Adnot and Saadia Eddahibi and B. Ma{\^i}tre},
  journal={Respiratory Research},
  year={2007},
  volume={8},
  pages={8 - 8}
}
BACKGROUND Bone marrow -derived cells (BMDCs) can either limit or contribute to the process of pulmonary vascular remodeling. Whether the difference in their effects depends on the mechanism of pulmonary hypertension (PH) remains unknown. OBJECTIVES We investigated the effect of BMDCs on PH induced in mice by either monocrotaline or exposure to chronic hypoxia. METHODS Intravenous administration of the active monocrotaline metabolite (monocrotaline pyrrole, MCTp) to C57BL/6 mice induced PH… CONTINUE READING

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