Effects of bleomycin on progression through the cell cycle of mouse L-cells.

  title={Effects of bleomycin on progression through the cell cycle of mouse L-cells.},
  author={Masahiko Watanabe and Y. Takabe and Tomoe Katsumata and Toyozo Terasima},
  journal={Cancer research},
  volume={34 4},
SUMMARY The effect of bleomycin on progression of mouse L-cells through the cell cycle was studied. In the presenceof bleo mycin, the beginning of DNA-synthetic (5) phase occurred at the same rate as that of the untreated control, but the duration was prolonged. In cells treated pulse-wise with bleomycin at the i phase, the prolongation of S phase was slight, whereasthe G2 phaseshoweda considerabledelay. Bleomycin also affected the entry of asynchronous cells into mitosis by arresting them at… CONTINUE READING

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