Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.

@article{Ghosh2004EffectsOB,
  title={Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.},
  author={Subhash Ch Ghosh and Julian Moreno Chan and Christopher R Lea and Gary A Meints and Jared C Lewis and Zev S Tovian and Ryan M Flessner and Timothy C Loftus and Iris Bruchhaus and Howard D Kendrick and Simon Croft and Robert G. Kemp and Seiki Kobayashi and Tomoyoshi Nozaki and Eric Oldfield},
  journal={Journal of medicinal chemistry},
  year={2004},
  volume={47 1},
  pages={
          175-87
        }
}
The effects of a series of 102 bisphosphonates on the inhibition of growth of Entamoeba histolytica and Plasmodium falciparum in vitro have been determined, and selected compounds were further investigated for their in vivo activity. Forty-seven compounds tested were active (IC(50) < 200 microM) versus E. histolytica growth in vitro. The most active compounds (IC(50) approximately 4-9 microM) were nitrogen-containing bisphosphonates with relatively large aromatic side chains. Simple n-alkyl-1… CONTINUE READING
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