Effects of biologically active tumour-promoting and non-promoting phorbol esters on in vitro growth of melanocytic cells.

@article{Brooks1990EffectsOB,
  title={Effects of biologically active tumour-promoting and non-promoting phorbol esters on in vitro growth of melanocytic cells.},
  author={Gavin Brooks and Mary Birch and Ian R. Hart},
  journal={Pigment cell research},
  year={1990},
  volume={3 2},
  pages={98-100}
}
Sapintoxin A (SAP A), a naturally occurring biologically active but non-promoting phorbol ester, acts as an effective in vitro mitogen for freshly derived human melanocytes. Seven days after addition of 50 nM SAP A there was a four to fivefold increase in melanocyte number over that observed in untreated control cultures comparable to that achieved with a 50 nM concentration of 12-0-tetradecanoylphorbol 13-acetate (TPA). The fluorescent stage 2 promoter sapintoxin D (SAP D) also supported the… CONTINUE READING

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