Effects of bile salts on propranolol distribution into liposomes studied by capillary electrophoresis.

@article{Yang2011EffectsOB,
  title={Effects of bile salts on propranolol distribution into liposomes studied by capillary electrophoresis.},
  author={Lin Yang and Ian G Tucker and Jesper \Ostergaard},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2011},
  volume={56 3},
  pages={553-9}
}
The objective of this study was to study the effect of four different bile salts, cholate (C), deoxycholate (DC), taurocholate (TC), monoketocholate (MKC), on the membrane binding of a cationic model drug, propranolol, using capillary electrophoresis. The apparent distribution coefficient of propranolol in a buffer/liposome system, in the absence and presence of various concentrations of the bile salts, was measured using capillary electrophoresis frontal analysis. At bile salt concentrations… CONTINUE READING