Effects of bile duct ligation on hepatic expression of female-specific CYP2C12 in male and female rats.

@article{Chen1998EffectsOB,
  title={Effects of bile duct ligation on hepatic expression of female-specific CYP2C12 in male and female rats.},
  author={Junbo Chen and Graham Robertson and Jacqueline Field and Christopher Liddle and Geoffrey C. Farrell},
  journal={Hepatology},
  year={1998},
  volume={28 3},
  pages={
          624-30
        }
}
Gender differences in hepatic sex steroid and drug metabolism result from hormonal regulation of specific cytochrome P450 genes (CYP). In male rats, bile duct ligation (BDL) is associated with down-regulation of the male-specific genes, CYP2C11 and CYP3A2, together with a decrease in serum testosterone levels and a two- to three-fold increase in serum estradiol concentrations. We anticipated that if estrogen is responsible for down-regulation of male-specific CYPs in BDL male rats, the female… CONTINUE READING

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