Effects of bilateral olfactory bulbectomy on N-methyl-D-aspartate receptor function: autoradiographic and behavioral studies in the rat.

@article{Robichaud2001EffectsOB,
  title={Effects of bilateral olfactory bulbectomy on N-methyl-D-aspartate receptor function: autoradiographic and behavioral studies in the rat.},
  author={Malika Robichaud and Vivienne Beauchemin and Normand Lavoie and Tom Dennis and Guy Debonnel},
  journal={Synapse},
  year={2001},
  volume={42 2},
  pages={95-103}
}
Rat bilateral olfactory bulbectomy (OBX) serves as a useful model in the study of depression and the mechanisms of action of antidepressant treatments. Considering the evidence of NMDA receptors involvement in depression, the present study was undertaken in order to investigate the time-course effects of OBX on the NMDA receptor function. Following bilateral olfactory bulbectomy, rats display an increase in locomotor activity and changes in other types of behavior in a novel environment… CONTINUE READING