Effects of bicarbonate on resting potentials in mammalian skeletal muscle.

@article{Grossie1985EffectsOB,
  title={Effects of bicarbonate on resting potentials in mammalian skeletal muscle.},
  author={J. Grossie},
  journal={Journal of cellular physiology},
  year={1985},
  volume={125 1},
  pages={
          115-21
        }
}
In the absence of external HCO3, resting membrane potentials (Vm) in extensor digitorum longus muscle were depolarized as compared to the normal Vm in the presence of HCO3. Removal of Na or Cl form the HCO3-free media induced repolarization. In muscle in HCO3 buffer at 20 degrees C, internal K, Na, and Cl activities were analyzed with liquid ion selective microelectrodes. The averages were respectively, 119.7 +/- 2.1, 6.69 +/- 0.3, and 3.41 +/- 0.06 mM. In a high proportion of cells analyzed… CONTINUE READING
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