Effects of bevacizumab on autocrine VEGF stimulation in bladder cancer cell lines.

  title={Effects of bevacizumab on autocrine VEGF stimulation in bladder cancer cell lines.},
  author={Paula Alexandra Videira and Ana Piteira and Maria de Guadalupe Cabral and Catarina Martins and Manuela Correia and Paulo F. Severino and Helena Gouveia and Myl{\`e}ne A. Carrascal and Joana F Almeida and H{\'e}lder Trindade and L{\'u}cio Lara Santos},
  journal={Urologia internationalis},
  volume={86 1},
INTRODUCTION A functional vascular endothelial growth factor A (VEGF-A) autocrine loop is crucial for bladder cancer cell survival. We reasoned that treatment with the anti-VEGF antibody bevacizumab may result either in cell growth prevention or in the cell adaptation to compensate VEGF deprivation. METHODS The cytotoxicity of different levels of bevacizumab and its effect on the gene expression was analyzed in human bladder cancer cell lines. RESULTS Inhibition of bladder cancer cell… CONTINUE READING


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Gene expression analysis in superficial bladder cancer: comparison of two suitable endogenous reference genes

  • PA Videira, D Ligeiro, M Correia, H Trindade
  • Curr Urol 2007;
  • 2007

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