Effects of beta-hydroxy-beta-methylbutyrate supplementation on strength and body composition in trained and competitive athletes: A meta-analysis of randomized controlled trials.

@article{SanchezMartinez2018EffectsOB,
  title={Effects of beta-hydroxy-beta-methylbutyrate supplementation on strength and body composition in trained and competitive athletes: A meta-analysis of randomized controlled trials.},
  author={Javier Sanchez-Martinez and Alejandro Santos-Lozano and Ant{\^o}nio Garc{\'i}a-Hermoso and Kabir P. Sadarangani and Carlos Cristi-Montero},
  journal={Journal of science and medicine in sport},
  year={2018},
  volume={21 7},
  pages={
          727-735
        }
}
Supplementation with the Leucine Metabolite β-hydroxy-β-methylbutyrate (HMB) does not Improve Resistance Exercise-Induced Changes in Body Composition or Strength in Young Subjects: A Systematic Review and Meta-Analysis
TLDR
It is concluded that HMB produces a small effect on TBM gain, but this effect does not translate into significantly greater increases in FFM, strength or decreases in FM during periods of RET.
Combined protein and calcium β-hydroxy-β-methylbutyrate induced gains in leg fat free mass: a double-blinded, placebo-controlled study
TLDR
Findings could explain some of the controversial effects of HMB reported in previous studies and have practical implications for maximizing training-induced gains in FFM and clinical conditions associated with skeletal muscle deconditioning such as aging, sedentary lifestyles, bed rest and spaceflight.
No effect of HMB or α-HICA supplementation on training-induced changes in body composition
Abstract β-hydroxy-β-methylbutyrate (calcium: HMB-Ca and free acid: HMB-FA) and α-hydroxyisocaproic acid (α-HICA) are leucine metabolites that have been proposed to improve body composition and
Effects of β-Hydroxy β-Methylbutyric Supplementation in Combination with Conservative Non-Invasive Treatments in Athletes with Patellar Tendinopathy: A Pilot Study
TLDR
The combination of eccentric training with stretching and ESWT increased concentric muscular power and strength after 4 weeks without changes in body lean mass or pain and HMB supplementation could enhance the power muscular performance in athletes with PT, optimizing the intervention adaptions.
Does HMB Enhance Body Composition in Athletes? A Systematic Review and Meta-analysis
TLDR
A systematic review and meta-analysis of the current literature on body composition in athletes suggests HMB may have a small, positive impact on FFM in athletes, although this seems specific to when protein intake is suboptimal.
Response to Effects of Reactiv "Maximum Beta-Hydroxy Beta-Methylbutyrate" on Body Mass and Performance in Elite Male Rugby Players.
TLDR
Overall, it seems that the findings of McIntosh et al. (3) are supported by the previous research suggesting HMB supplementation is not beneficial to elite rugby players, highlighting a key issue for athletes that despite due diligence in supplement procurement, they still may not be obtaining the supplement they believe.
A Review of the Effects of Leucine Metabolite (β-Hydroxy-β-methylbutyrate) Supplementation and Resistance Training on Inflammatory Markers: A New Approach to Oxidative Stress and Cardiovascular Risk Factors
TLDR
The data presented here suggest that acute HMB supplementation may attenuate the pro-inflammatory response following an intense bout of resistance exercise in athletes and that chronic HMB consumption with resistance training does not improve cardiovascular risk factors and oxidative stress markers greater than resistance training alone.
Time-restricted feeding plus resistance training in active females: a randomized trial
TLDR
IF, in the form of TRF, did not attenuate RT adaptations in resistance-trained females and similar FFM accretion, skeletal muscle hypertrophy, and muscular performance improvements can be achieved with dramatically different feeding programs that contain similar energy and protein content during RT.
Leucine Metabolites Do Not Enhance Training-induced Performance or Muscle Thickness
TLDR
Assessment of the effects of off-the-shelf leucine metabolite supplements on resistance training-induced changes in muscle thickness and performance in young adult men concluded that Supplementation withLeucine metabolites—&agr;-HICA, H MB-FA, or HMB-Ca—is not a supplementation strategy that improves muscle growth and strength development in youngAdult men.
Supplements with purported effects on muscle mass and strength
TLDR
There is little evidence supporting the use of most supplements, and some of them have been even proven ineffective or potentially associated with adverse effects.
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The results indicate that HMB intake in endurance training has an advantageous effect on the increase in aerobic capacity and the reduction of fat mass and on other indices of anaerobic adaptation and levels of investigated markers in the blood.
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TLDR
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