• Corpus ID: 28050975

Effects of beta adrenoceptor down-regulation on the cardiovascular responses to the stereoisomers of dobutamine.

@article{Hayes1985EffectsOB,
  title={Effects of beta adrenoceptor down-regulation on the cardiovascular responses to the stereoisomers of dobutamine.},
  author={James Scott Hayes and Nancy Bowling and G. Donald Pollock},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1985},
  volume={235 1},
  pages={
          58-65
        }
}
Effects of prolonged in vivo infusion of either saline (control) or isoproterenol (beta adrenoceptor desensitization) on acute cardiovascular responses to (+) (beta agonist)-, (-) (alpha agonist)- and (+/-)-dobutamine were studied in pithed rats. Each form of dobutamine resulted in comparable dose-dependent increases in maximum left ventricular dP/dt (LVdP/dtmax) in control animals. Effects of (+)-dobutamine were blocked by propranolol whereas those of l-dobutamine were sensitive to prazosin… 

Chronotropic and inotropic responses to adrenoceptor agonists in vitro after chronic dobutamine treatment in the rabbit.

  • M. Brown
  • Biology, Medicine
    Journal of autonomic pharmacology
  • 1992
These changes are consistent with functional desensitization of the myocardium by the prolonged beta- but not alpha 1-agonist activity of dobutamine, and there was an enhanced effectiveness of beta-adrenoceptor activation.

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IV. Neurohumoral Mechanisms in Heart Failure /3-Adrenergic Inotropic Responsiveness of Patients With Heart Failure: Studies With Intracoronary Dobutamine Infusion

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