Effects of benzyl isothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1.

Abstract

Naturally occurring isothiocyanates, such as benzyl isothiocyanate (BITC), are potent and selective inhibitors of carcinogenesis induced by a variety of chemical carcinogens. These effects appear to be mediated through favorable modification of both phase I and II enzymes involved in carcinogen metabolism. The inactivation of rat and human cytochromes P450… (More)

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@article{Goosen2001EffectsOB, title={Effects of benzyl isothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1.}, author={Tanya Goosen and D. E. Mills and Paul F. Hollenberg}, journal={The Journal of pharmacology and experimental therapeutics}, year={2001}, volume={296 1}, pages={198-206} }