Effects of benzquinamide, in comparison with chlordiazepoxide and placebo, on subjective experiences and autonomic phenomena in stress experiments


Benzquinamide was compared to chlordiazepoxide and placebo in a triple-blind study. Doses within the clinical range were used. The subjective experiences with the respective preparations as well as autonomic changes during experimental stress (under the influence of the respective preparations) were recorded. Benzquinamide did not show any more positive subjective effects than placebo and produced mainly unpleasant effects. Chlordiazep-oxide differed favourably from both placebo and benzquinamide and showed several significant positive effects indicating well-being and friendliness, while it had remarkably few disagreeable effects. The autonomic findings, although few, in all respects supported the subjectively reported effects. Chlordiazepoxide showed better abilities than benzquinamide to counteract as well autonomic as emotional effects of stress. Chlordiazepoxide in this and a previous study was found to possess valuable properties as a tranquilizer, while benzquinamide did not at all show promising properties.

DOI: 10.1007/BF00413051
Showing 1-10 of 11 references

GERS]tON: Autonomic and psychic effects of yohimbine hydroehloride

  • 1961
Highly Influential
5 Excerpts

GATES: Performance in human subjects under auditory feedback after alcohol, a tranquilizer (benzquinamide) or benzquinamide-Meohol combination

  • F. W. HuGHs, P.W.R.B. FORNEY
  • 1963

STEELE: A controlled evaluation of benzquinamide: Behavioral toxicity with high dosage levels in schizophrenics

  • A. C
  • 1963
1 Excerpt

The effects of benzquinamide

  • M. E. SIIT
  • 1963

YVILLIAM-0LSSON: The effect of benzquinamide, in comparison with chlordiazepoxide and placebo, on performance in some psychological tests

  • 1963

KURLAND: Benzquinamide in the treatment of the psychotic patient

  • K. NussBAu, A.A.J. McCusKER
  • 1962

BAYDAN: Effects of chronic administration of Librium and of one of its analogs on human somatic responses

  • 1961

BECK: A systematic study of autonomic drug actions in mental hospital patients: Methodology and preliminary results

  • G. HOLBERG, L. H
  • 1961

SVTER: The effects of ethanol and chlordiazepoxide in altering autonomic responses evoked by isoeortical and paleocortical stimulation

  • M. N. CARROLL ir, E. C. HOFF, C.G.J. '. -ELL
  • 1961


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