Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat

@article{Cole2005EffectsOB,
  title={Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat},
  author={B. J. Cole and M. Hillmann and D. Seidelmann and M. Klewer and Graham H. Jones},
  journal={Psychopharmacology},
  year={2005},
  volume={121},
  pages={118-126}
}
The present series of experiments examined the effects of five benzodiazepine receptor (BZR) partial inverse agonists on the behaviour of rats on an elevated plus maze. The drugs were tested in a standard plus maze with 3-cm walls added to the open arms, as this has been shown to increase the sensitivity of the plus maze to anxiogenic-like drug effects (Jones and Cole 1995). The drugs tested were FG 7142 (0–100 mg/kg),β-CCE (0–30 mg/kg), ZK 132 556 (0–100 mg/kg), ZK 90 886 (0–30 mg/kg) and Ro… Expand
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