Effects of benzodiazepine agonist, inverse agonist and antagonist drugs in the mouse staircase test

@article{Emmanouil1990EffectsOB,
  title={Effects of benzodiazepine agonist, inverse agonist and antagonist drugs in the mouse staircase test},
  author={Dimitris E. Emmanouil and Raymond M. Quock},
  journal={Psychopharmacology},
  year={1990},
  volume={102},
  pages={95-97}
}
This study examined the effects of the benzodiazepine agonist midazolam and inverse agonist noreleagnine independently and in conjunction with the antagonist flumazenil in the mouse staircase test. According to this paradigm, the numbers of steps ascended (NSA) and rears (NR) reflect locomotor activity and anxiety, respectively. Midazolam reduced NR at doses that did not affect NSA; this NR-lowering effect was blocked by flumazenil. Noreleagnine increased NR at doses that did not affect NSA… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
12 Citations
18 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 18 references

Similar Papers

Loading similar papers…