Effects of benserazide and carbidopa on the metabolism of L-tryptophan by isolated rat liver cells.

  title={Effects of benserazide and carbidopa on the metabolism of L-tryptophan by isolated rat liver cells.},
  author={S. A. Smith and Christopher I. Pogson},
  journal={Biochemical pharmacology},
  volume={30 6},
8 Citations

Effects of Tranilast on the Urinary Excretion of Kynurenic and Quinolinic Acid Under Conditions of L Tryptophan Loading

  • R. Noakes
  • Biology, Chemistry
    International journal of tryptophan research : IJTR
  • 2013
The data suggest that tranilast acts as a competitive inhibitor of either indoleamine 2, 3-dioxygenase (IDO), tryptophan 2,3 di-oxygenases (TDO) or both, and demonstrates a therapeutic response to manipulation of the kynurenine pathway.

Suppression and potentiation of 5‐hydroxytryptophan‐induced hypoglycaemia by α‐monofluoromethyldopa: correlation with the accumulation of 5‐hydroxytryptamine in the liver

  • Y. Endo
  • Biology, Medicine
    British journal of pharmacology
  • 1987
The results further support the hypothesis that the accumulation of 5‐HT in the liver is causally related to the hypoglycaemia induced by 5‐ HTP and indicate that the LPS‐induced 5-HT accumulation in the Liver is not derived from stimulation of5‐HT synthesis.

The Aryl Hydrocarbon Receptor: A Review of Its Role in the Physiology and Pathology of the Integument and Its Relationship to the Tryptophan Metabolism

  • R. Noakes
  • Biology
    International journal of tryptophan research : IJTR
  • 2015
The role AHR plays in the development, cellular oxidation/antioxidation, responses to ultraviolet light, melanogenesis, epidermal barrier function, and immune regulation and its relationship to tryptophan metabolism is reviewed.

Biochemistry of tryptophan in health and disease.

  • D. Bender
  • Biology
    Molecular aspects of medicine
  • 1983



The metabolism of L-tryptophan by isolated rat liver cells. Quantification of the relative importance of, and the effect of nutritional status on, the individual pathways of tryptophan metabolism.

The metabolism of L-tryptophan by liver cells prepared from fed and 48 h-starved rats was studied and tryptophan was degraded exclusively through kynurenine; there was no evidence of formation of either indol- 3-ylacetic acid or 5-hydroxyindol-3-ylACetic acid.

The metabolism of L-tryptophan by isolated rat liver cells. Effect of albumin binding and amino acid competition on oxidatin of tryptophan by tryptophan 2,3-dioxygenase.

It is concluded that alterations in free tryptophan concentrations consequent to changes in albumin binding may be an important factor in regulating tryPTophan uptake and catabolism by the liver.

The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors.

The possibility that pyruvate transport into mitochondria may be rate limiting and involved in the regulation of gluconegenesis is discussed, and alpha-cyano-4-hydroxycinnamate was shown to be accompanied by the transport of a proton (or by exchange with an OH-ion), which allowed measurements of pyruVate transport at higher temperatures to be made.