Effects of benoxaprofen on the binding to and inactivation of leucoattractants by human polymorphonuclear leucocytesin vitro

@article{Anderson2005EffectsOB,
  title={Effects of benoxaprofen on the binding to and inactivation of leucoattractants by human polymorphonuclear leucocytesin vitro},
  author={R. Anderson and Pauline T. Lukey and Constance E.J. Van Rensburg},
  journal={Agents and Actions},
  year={2005},
  volume={16},
  pages={527-534}
}
Benoxaprofen was previously found to inhibit the random and leucoattractant-induced migration of human polymorphonuclear leucocytesin vitro by a pro-oxidative mechanism [1]. In this study the effects of benoxaprofen on the binding to PMNL of the synthetic chemotactic tripeptide FMLP, on the oxidative inactivation of this leucoattractant by PMNL and on PMNL chemotaxis, chemokinesis and orientation in an FMLP gradient have been investigated. At concentrations of 10−5M (3 μg/ml) benoxaprofen… Expand

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The present experiments demonstrate that the peptide chemoattractant serves as a sufficient secretory stimulus to trigger its own functional inactivation by neutrophils, and support the pathophysiologic significance of oxidative inactivation of humoral mediators as a negative feedback inflammatory control mechanism. Expand
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Polymorphonuclear leukocyte (PMN) chemotaxis has been examined under conditions which allow phase microscope observations of cells responding to controlled gradients of chemotactic factors and, at high cell densities, PMNs incubated with active peptides orient their locomotion away from the center of the cell population. Expand
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