Effects of barbiturates on inhibitory and excitatory responses to applied neurotransmitters in Aplysia.

@article{Cote1980EffectsOB,
  title={Effects of barbiturates on inhibitory and excitatory responses to applied neurotransmitters in Aplysia.},
  author={I L Cote and Wilkie A. Wilson},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1980},
  volume={214 1},
  pages={161-5}
}
The effects of barbiturates on responses to iontophoretically applied acetylcholine and gamma-aminobutyric acid were studied in Aplysia californica by using a voltage clamp. Dose-response data were obtained for barbiturate concentrations ranging from 1 microM to 3 mM. Both phenobarbital and pentobarbital depress chloride-dependent inhibitory responses to both acetylcholine and gamma-aminobutyric acid. This depression occurs at approximately the same concentrations which attenuate excitatory… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.