Effects of baclofen on dopamine-dependent behaviors in mice

  title={Effects of baclofen on dopamine-dependent behaviors in mice},
  author={Jehangir J. Balsara and M. P. Muley and A. S. Vaidya and A. G. Chandorkar},
Baclofen, the parachlorophenyl analog of GABA, was found to induce catalepsy and to inhibit the traction response in mice. However, baclofen pretreatment, instead of antagonizing methamphetamine stereotypy and apomorphine-induced cage climbing behavior, was found to potentiate these behaviors, thereby ruling out the possibility of its possessing postsynaptic dopamine (DA) receptor blocking activity. The possible mechanism involved in the induction of catalepsy and in the inhibition of the… CONTINUE READING


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