Effects of atorvastatin on bone metabolism and bone mineral density in Wistar rats.

@article{Chang2011EffectsOA,
  title={Effects of atorvastatin on bone metabolism and bone mineral density in Wistar rats.},
  author={Bao Cheng Chang and Juhong Yang and Hechao Li and Shan Lu and Liming Chen and Peihua Fang},
  journal={Die Pharmazie},
  year={2011},
  volume={66 7},
  pages={535-7}
}
OBJECTIVE To investigate the effects of atorvastatin on bone formation, bone resorption and bone mineral density in Wistar rats. METHODS Sixty healthy male Wistar rats were randomly divided into one control group treated with vehicle alone and three drug treatment groups, which were treated with atorvastatin at 5 mg/kg x d, 25 mg/kg x d and 50 mg/kg x d respectively. Left femur BMD and bone metabolic parameters were measured after 8 weeks of treatment. In high dose of atorvastatin group, 20… CONTINUE READING
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