Effects of atazanavir/ritonavir and lopinavir/ritonavir on glucose uptake and insulin sensitivity: demonstrable differences in vitro and clinically.

@article{Noor2006EffectsOA,
  title={Effects of atazanavir/ritonavir and lopinavir/ritonavir on glucose uptake and insulin sensitivity: demonstrable differences in vitro and clinically.},
  author={M. Aeny Rochman Noor and Oliver P. Flint and Jerome P.-Y. Maa and Rex A. Parker},
  journal={AIDS},
  year={2006},
  volume={20 14},
  pages={
          1813-21
        }
}
BACKGROUND The HIV protease inhibitor (PI) atazanavir does not impair insulin sensitivity acutely but ritonavir and lopinavir induce insulin resistance at therapeutic concentrations. OBJECTIVE To test the hypothesis that atazanavir combined with a lower dose of ritonavir would have significantly less effect on glucose metabolism than lopinavir/ritonavir in vitro and clinically. METHODS Glucose uptake was measured following insulin stimulation in differentiated human adipocytes in the… CONTINUE READING
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