Effects of astragaloside IV on action potentials and ionic currents in guinea-pig ventricular myocytes.

@article{Zhao2013EffectsOA,
  title={Effects of astragaloside IV on action potentials and ionic currents in guinea-pig ventricular myocytes.},
  author={Meimi Zhao and Jinsheng Zhao and Guilin He and Xue-fei Sun and Xueshi Huang and Liying Hao},
  journal={Biological & pharmaceutical bulletin},
  year={2013},
  volume={36 4},
  pages={515-21}
}
Astragaloside IV (AS-IV) is one of the main active constituents of Astragalus membranaceus, which has various actions on the cardiovascular system. However, its electrophysiological mechanisms are not clear. In the present study, we investigated the effects of AS-IV on action potentials and membrane currents using the whole-cell patch clamp technique in isolated guinea-pig ventricular myocytes. AS-IV prolonged the action potential duration (APD) at all three tested concentrations. The peak… CONTINUE READING
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