Effects of aspirin on platelet-neutrophil interactions. Role of nitric oxide and endothelin-1.

@article{LpezFarr1995EffectsOA,
  title={Effects of aspirin on platelet-neutrophil interactions. Role of nitric oxide and endothelin-1.},
  author={Antonio L{\'o}pez-Farr{\'e} and Carlos A. Caramelo and Alfredo Esteban and M L Alberola and Inmaculada Mill{\'a}s and Mercedes Mont{\'o}n and S. Pulido Casado},
  journal={Circulation},
  year={1995},
  volume={91 7},
  pages={2080-8}
}
BACKGROUND In recent studies, the hypothesis has been raised that the mechanisms by which aspirin acts as a protective anti-ischemic agent exceed the inhibition of platelet thromboxane A2 synthesis. Recently, new data have been obtained disclosing a platelet-antiaggregating effect by neutrophils, which occurs through a nitric oxide (NO)/cGMP-dependent pathway. METHODS AND RESULTS The present study, using platelets and neutrophils from normal subjects, was undertaken to assess the putative… CONTINUE READING

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