Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the rat.

@article{McLean2010EffectsOA,
  title={Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the rat.},
  author={Samantha L. McLean and Joanna C. Neill and N. Fadilah Idris and Hugh M. Marston and Erik H. F. Wong and Mohammed Abdul Shahid},
  journal={Behavioural brain research},
  year={2010},
  volume={214 2},
  pages={240-7}
}
BACKGROUND Asenapine is a new pharmacological agent for the acute treatment of schizophrenia and bipolar disorder. It has relatively higher affinity for serotonergic and alpha(2)-adrenergic than dopaminergic D(2) receptors. We evaluated the effects of asenapine, risperidone, and olanzapine on acute and subchronic psychotomimetic-induced disruption of cued reversal learning in rats. METHODS After operant training, rats were treated acutely with d-amphetamine (0.75 mg/kg intraperitoneally [i.p… CONTINUE READING
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Asenapine restores cognitiveflexibil - ity in rats with medial prefrontal cortex lesions

  • MarstonHM TaitDS, BrownVJ ShahidM
  • Psychopharmacology ( Berlin )
  • 2009

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