Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balance.

@article{Negishi2005EffectsOA,
  title={Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balance.},
  author={Takaaki Negishi and Yutaka Kato and Osamu Ooneda and Junsei Mimura and Tomonari Takada and Hidenori Mochizuki and Masayuki Yamamoto and Yoshiaki Fujii-Kuriyama and Shoji Furusako},
  journal={Journal of immunology},
  year={2005},
  volume={175 11},
  pages={
          7348-56
        }
}
An orally active antiallergic agent, M50367, skews the Th1/Th2 balance toward Th1 dominance by suppressing naive Th cell differentiation into Th2 cells in vitro. Administration results in the suppression of IgE synthesis and peritoneal eosinophilia in vivo. In this report, we determined that M50354 (an active metabolite of M50367) was a ligand for the aryl hydrocarbon receptor (AhR); the immunological effects of this compound on in vitro Th1/Th2 differentiation from naive Th cells and Th1/Th2… CONTINUE READING

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