Effects of artemisinin-tagged holotransferrin on cancer cells.

@article{Lai2005EffectsOA,
  title={Effects of artemisinin-tagged holotransferrin on cancer cells.},
  author={Henry C. Lai and Tomikazu Sasaki and Narendra Singh and Archna Messay},
  journal={Life sciences},
  year={2005},
  volume={76 11},
  pages={
          1267-79
        }
}
Artemisinin reacts with iron to form free radicals that kill cells. Since cancer cells uptake relatively large amount of iron than normal cells, they are more susceptible to the toxic effect of artemisinin. In previous research, we have shown that artemisinin is more toxic to cancer cells than to normal cells. In the present research, we covalently attached artemisinin to the iron-carrying plasma glycoprotein transferrin. Transferrin is transported into cells via receptor-mediated endocytosis… 
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Simple artemisinin analogs are less potent than traditional cancer chemotherapeutic agents and have short plasma half-lives, and would require high dosage and frequent administration to be effective for cancer treatment.
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Effects of transferrin conjugates of artemisinin and artemisinin dimer on breast cancer cell lines.
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Various compounds of the artemisinin family are currently used for the treatment of patients with malaria worldwide. They are characterised by a short half-life and feature the most rapidly acting
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