Effects of arsenic trioxide, all-trans-retinoic acid and dexamethasone on NB4 cell line

BACKGROUND AND THE PURPOSE OF THE STUDY Experimental and preclinical observations have indicated that combination therapy with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) may strongly enhance their therapeutic effects in the treatment of acute promyelocytic leukemia (APL). Whilst dexamethasone (Dex) is routinely used for the control of APL… (More)