Effects of arsenic exposure on DNA methylation and epigenetic gene regulation.

  title={Effects of arsenic exposure on DNA methylation and epigenetic gene regulation.},
  author={John F. Reichard and Alvaro Puga},
  volume={2 1},
Arsenic is a nonmutagenic human carcinogen that induces tumors through unknown mechanisms. A growing body of evidence suggests that its carcinogenicity results from epigenetic changes, particularly in DNA methylation. Changes in gene methylation status, mediated by arsenic, have been proposed to activate oncogene expression or silence tumor suppressor genes, leading to long-term changes in the activity of genes controlling cell transformation. Mostly descriptive, and often contradictory… 

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