• Corpus ID: 12249812

Effects of arotinoids upon murine embryonal carcinoma cells.

@article{Sherman1983EffectsOA,
  title={Effects of arotinoids upon murine embryonal carcinoma cells.},
  author={Michael I. Sherman and Maria Paternoster and Makoto Mark Taketo},
  journal={Cancer research},
  year={1983},
  volume={43 9},
  pages={
          4283-90
        }
}
Five arotinoids have been compared with all-trans- and 13-cisretinoic acids for their ability to promote differentiation of cells from murine embryonal carcinoma line Nulli-SCC1. Ro-13-7410, which contains a terminal carboxylic acid residue, and Ro-14-9572, the sodium sulfinate derivative, are potent inducers of differentiation. The sodium sulfonate derivative, Ro-14-3899, is somewhat less active, whereas the ethyl sulfone (Ro-15-1570) and Ro-15-0778, an arotinoid lacking a terminal group, have… 
View on PubMed
cancerres.aacrjournals.org
33 Citations
Background Citations
5
Methods Citations
1

Figures and Tables from this paper

33 Citations

The effects of retinoid treatment and antiestrogens on the growth of T47D human breast cancer cells.

New benzoic acid derivatives with retinoid activity: lack of direct correlation between biological activity and binding to cellular retinoic acid binding protein.

Results show that the Am- and Ch- derivatives elicit in several cell systems the same cellular responses as retinoic acid, and it is proposed that they exhibit mechanism(s) of action) similar to those of retinoids.

Inhibition of rat mammary carcinogenesis by an arotinoid without a polar end group (Ro 15-0778).

Effect of a new retinoidal benzoic acid derivative on normal human hematopoietic progenitor cell growth in vitro.

Data demonstrate that TTNPB is more active than RA in stimulating the growth of hemopoietic progenitors from normal marrows, and may have therapeutic implications for various hemopOietic disorders.

Structure-activity relationships of aromatic retinoids on the differentiation of the human histiocytic lymphoma cell line U-937.

Role of retinoids in differentiation and growth of embryonal carcinoma cells.

It is suggested that EC cells can become epigenetically refractory to RA, since some cells are unaffected even by lengthy exposures to RA whereas the growth of their progeny is inhibited.

Sodium butyrate induces histone hyperacetylation and differentiation of murine embryonal carcinoma cells

Observations suggest that sodium butyrate has the ability to reactivate a silent cRABP gene in PCC4(RA)-1 cells and thereby lead to extensive differentiation via the retinoid pathway when RA is added.

Effect of retinoids on the growth, ultrastructure, and cytoskeletal structures of malignant rat osteoblasts.

The results identify this clonal rat osteogenic sarcoma cell line, which has been extensively characterized as the malignant counterpart of the normal osteoblast, as a target for vitamin A action.

Teratogenicity of benzoic acid derivatives of retinoic acid in cultured mouse embryos.

The growth-supporting activity of a retinoidal benzoic acid derivative and 4,4-difluororetinoic acid.

References

SHOWING 1-10 OF 22 REFERENCES

Possible role of retinoic acid binding protein in retinoid stimulation of embryonal carcinoma cell differentiation

It is shown that retinoic acid not only stimulates the differentiation of Pluripotent embryonal carcinoma cell lines, but also induces differentiation of the so-called nullipotent embryo-like cells, nulli SCC1 and 6050 AJ, and evidence is presented to suggest that the action of retinoids may be mediated by a retinoIC acid binding protein.

Studies on the effect of retinoids on the differentiation of teratocarcinoma stem cells in vitro and in vivo.

Stimulation of differentiation of several murine embryonal carcinoma cell lines by retinoic acid.

Isolation and characterization of mouse mutant embryonal carcinoma cells which fail to differentiate in response to retinoic acid.

The results strengthen the view that differentiation of embryonal carcinoma cells in response to retinoic acid requires formation of retinic acid-cytoplasmic retinoIC acid-binding protein complexes.

STUDIES ON THE MECHANISM OF INDUCTION OF EMBRYONAL CARCINOMA CELL DIFFERENTIATION BY RETINOIC ACID

It is concluded that RA is a potent promoter of differentiation of EC cells and some function of the RA-RABP complex is critical in the sequence of events leading to differentiation ofEC cells.

Differentiation-defective mutants of mouse embryonal carcinoma cells: response to hexamethylenebisacetamide and retinoic acid.

Conversion of malignant murine embryonal carcinomas to benign teratomas by chemical induction of differentiation in vivo.

In 4 of 18 cases, long-term survival of the hosts was effected by a complete differentiation of the malignant embryonal carcinoma tumors into benign teratomas, and retinoic acid:dimethylacetamide was effective in inducing differentiation with the same dosage and schedule when administered systemically.

The induction of differentiation in teratocarcinoma stem cells by retinoic acid

Rescue of terminally differentiating teratocarcinoma cells by fusion to undifferentiated parental cells

These experiments indicate that the undifferentiated cells can “rescue” cells in the initial stages of differentiation and that the signs of differentiation are soon lost in such hybrids.

Relationship between binding affinities to cellular retinoic acid-binding protein and in vivo and in vitro properties for 18 retinoids.

While all retinoids that are potent in these biological test systems bind tightly to cellular retinoic acid-binding protein, the converse is not true and the lack of a consistent quantitative correlation between 50% inhibitory concentration and biological activity is probably due to insufficient concentrations of the retinoid in the target tissue or celll.