Effects of aromatic cationic molecules on bovine viral diarrhea virus and embryonic development.

@article{Givens2005EffectsOA,
  title={Effects of aromatic cationic molecules on bovine viral diarrhea virus and embryonic development.},
  author={M. Daniel Givens and Patricia K. Galik and Kay P. Riddell and Christine C. Dykstra and Kenny V. Brock and David A. Stringfellow},
  journal={Theriogenology},
  year={2005},
  volume={63 7},
  pages={
          1984-94
        }
}
Bovine viral diarrhea virus (BVDV) has been shown to replicate in embryo culture systems and remain associated with bovine embryos developing in vitro. In this study, novel antiviral agents were evaluated for capability to inhibit replication of BVDV without affecting embryonic development. Serial concentrations of 2-[5(6)-{2-imidazolinyl}-2-benzimidazolyl]-5-(4-aminophenyl)furan (DB456) or 2-(4-[2-imidazolinyl]phenyl)-5-(4-methoxyphenyl)furan (DB606) were prepared in IVC medium. Then, bovine… 
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Effect of treatment with a cationic antiviral compound on acute infection with bovine viral diarrhea virus.
  • B. Newcomer, M. Marley, +7 authors M. Givens
  • Biology, Medicine
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
  • 2013
TLDR
This pilot study indicates that DB772 temporarily prevented acute disease due to BVDV, but carries a significant concern of renal toxicity.
Normal calves produced after transfer of in vitro fertilized embryos cultured with an antiviral compound.
TLDR
Evaluating the capability of IVF embryos to develop into normal, weaned calves after exposure to antiviral concentrations of DB606 during IVC concluded that bovine embryo cultures can be safely supplemented with antiviral Concentrations DB606; addition ofDB606 agent might prevent viral transmission if BVDV were inadvertently introduced into the embryo culture system.
Normal reproductive capacity of heifers that originated from in vitro fertilized embryos cultured with an antiviral compound.
TLDR
Results indicate that culture of bovine-IVF embryos in DB606 does not impair future reproductive capacity of resulting heifers.
Antiviral Treatment of Calves Persistently Infected with Bovine Viral Diarrhoea Virus
TLDR
Results demonstrate that DB772 administration is safe and exhibits antiviral properties in PI calves while facilitating the rapid development of viral resistance to this novel therapeutic agent.
The means of combating persistent infection of viral diarrhea
TLDR
Application of antiviral drugs is one of the ways to decrease economic losses caused by biological product contamination, the use of persistently infected animals for pedigree purposes and restrictions in international cattle trade.
Molecular Modeling of Small Molecules as BVDV RNA-Dependent RNA Polymerase Allosteric Inhibitors
Bovine viral diarrhea virus (BVDV), a major pathogen of cattle, is a well-characterized pestivirus which has been used as a good model virus for HCV. The RNA-dependent RNA polymerase (RdRp) plays a…
Potential applications for antiviral therapy and prophylaxis in bovine medicine
TLDR
This review summarizes the current state of knowledge of antiviral compounds against several key bovine pathogens and the potential for commercial antiviral applications in the prevention and control of several selected bovines diseases.
Risk assessment of transmission of bovine viral diarrhea virus (BVDV) in abattoir-derived in vitro produced embryos.
  • G. Perry
  • Biology, Medicine
    Theriogenology
  • 2007
TLDR
To estimate the risk of producing infected recipients and persistently infected calves from abattoir-derived IVP embryos, a quantitative risk assessment model using Microsoft Excel and Palisade @Risk was developed and assumed some of the complexities of the IVP process.
Database construction of small–molecule inhibitors as bovine viral diarrhea virus (BVDV) RNA-dependent RNA polymerase: a cheminformatics approach
TLDR
A database of 655 small-molecule NS5B inhibitors having definitive activity values, structural parameters, and physicochemical properties associated with their absorption and permeability through a cheminformatics approach is constructed to provide insight for allosteric NS5Bs of BVDV with an accessible platform on the web.
Bovine viral diarrhea virus (BVDV): epidemiologic concerns relative to semen and embryos.
TLDR
An overview of the risks of transmitting this virus by AI or production and transfer of embryos and summarizes the precautions needed to prevent such transmissions of disease from occurring is provided.
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