Effects of aromatic cationic molecules on bovine viral diarrhea virus and embryonic development.

  title={Effects of aromatic cationic molecules on bovine viral diarrhea virus and embryonic development.},
  author={M. Givens and P. Galik and K. Riddell and C. Dykstra and K. Brock and D. Stringfellow},
  volume={63 7},
  • M. Givens, P. Galik, +3 authors D. Stringfellow
  • Published 2005
  • Biology, Medicine
  • Theriogenology
  • Bovine viral diarrhea virus (BVDV) has been shown to replicate in embryo culture systems and remain associated with bovine embryos developing in vitro. In this study, novel antiviral agents were evaluated for capability to inhibit replication of BVDV without affecting embryonic development. Serial concentrations of 2-[5(6)-{2-imidazolinyl}-2-benzimidazolyl]-5-(4-aminophenyl)furan (DB456) or 2-(4-[2-imidazolinyl]phenyl)-5-(4-methoxyphenyl)furan (DB606) were prepared in IVC medium. Then, bovine… CONTINUE READING
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