Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats.

@article{Hirose2000EffectsOA,
  title={Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats.},
  author={Masao Hirose and Tsuyoshi Yamaguchi and Chin-Wen Lin and Naoya Kimoto and Mitsuru Futakuchi and Taichi Kono and Sansei Nishibe and Tomoyuki Shirai},
  journal={Cancer letters},
  year={2000},
  volume={155 1},
  pages={79-88}
}
Chemopreventive effects of arctiin, a lignan isolated from Arctium lappa (burdock) seeds, on the initiation or post initiation period of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced mammary carcinogenesis in female rats and on 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-associated hepatocarcinogenesis in male rats were examined. In experiment 1, female Sprague-Dawley (SD) rats were given intragastric doses of 100 mg/kg body wt of PhIP once a week for 8 weeks as… CONTINUE READING

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