Effects of arabinonucleotides on ribonucleotide reduction by an enzyme system from rat tumor.

  title={Effects of arabinonucleotides on ribonucleotide reduction by an enzyme system from rat tumor.},
  author={E. Colleen Moore and S. S. Cohen},
  journal={The Journal of biological chemistry},
  volume={242 9},
  • E. MooreS. Cohen
  • Published 10 May 1967
  • Biology, Chemistry, Computer Science
  • The Journal of biological chemistry

Irreversible inhibition of ribonucleotide reductase from Ehrlich tumor cells by a modulator analog.

Metabolic effets of nucleosides in rat thymus cells in vitro

Cells incubated in the presence of adenosine showed a decreased labelling of deoxynucleotides and DNA due to inhibition of earlier steps in utilization of the labelled precursor, its uptake and phosphorylation, and an effect on the reductase was indicated.

Inhibition of salvage pathway enzymes by adenine arabinoside 5′-monophosphate (ara-AMP)

The possible adverse drug interactions which might occur by the simultaneous use of ara-AMP and other antimetabolites are discussed.

Inhibition of bacterial ribonucleotide reductases by arabinonucleotides.

Alosteric modification of enzyme activity is always determined by the individual combination of sugar and base structures, in accord with the specificities and effector patterns of the enzymes known for natural nucleotides.

Selective inhibition of nuclear DNA synthesis by 9- -D-arabinofuranosyl adenine in rat cells transformed by Rous sarcoma virus.

  • C. ShipmanS. SmithJ. Drach
  • Chemistry, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1972
The drug, 9-beta-D-arabinofuranosyl adenine, selectively inhibits the synthesis of nuclear DNA without affecting extrachromosomal DNA synthesis in rat cells transformed by Rous sarcoma virus (B-mix

Effect of 1-beta-D-arabinofuranosylcytosine triphosphate on DNA synthesis in isolated HeLa cell nuclei.

Neither the rate nor the extent of [3H]TTP incorporation into DNA decreased when such nuclei were incubated in the absence of ara-CTP, but the rate of ligation of primary pieces was reduced.

Studies on the Mechanism of Action of 1-0-D-Arabinofuranosylcy tosine as an Inhibitor of DNA Synthesis in Human Leukemic Leukocytes1

It was shown that ara-C inhibited, to some extent, activities of crude DNA polymerases from both human leukemic leukocytes and Ehrlich ascites tumor cells, suggesting that the primary site of action of aRA-C might not be at the level of reduction of CDP to dCDP in humanLeukocytes.